Disabled List-Major Fantasy Impact Players
| Name | Position | Injury | Expected Return |
| Tim Hudson | SP | Elbow | Early August |
| Daisuke Matsuzaka | SP | Shoulder | Mid May |
| Alex Gordon | 3B | HIp | Early July |
| Ervin Santana | SP | Elbow | Mid-May |
| John Lackey | SP | Forearm | Mid-May |
| Vladimir Guerrero | OF | Pectoral | Late-May |
| Chris Carpenter | SP | Oblique | Late-May to Early-June |
| Ching Ming Wang | SP | Hip | Late May |
| B.J. Ryan | RP | Back | Mid-May |
| Xavier Nady | OF | Shoulder | Late-June |
| Carlos Zambrano | SP | Hamstring | Mid, Late-May |
| Brandon Webb | SP | Shoulder | Mid-May |
