Johan Santana (Left) and Tim Lincecum (Right) were predicted by us to be the top two pitchers in this upcoming fantasy year. You may believe that based on last year's stats Lincecum is the better pick, but he is still very young and had only one truly dominate season. On the other hand, Johan Santana is in his prime and had established consistent dominance throughout his career.
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| Players | Rank | Wins | Losses | Strike Outs | ERA | WHIP |
| Johan Santana | 1 | 17 | 6 | 211 | 2.64 | 1.13 |
| Tim Lincecum | 2 | 15 | 7 | 272 | 2.47 | 1.15 |
| CC Sabathia | 3 | 19 | 5 | 245 | 2.98 | 1.12 |
| Cole Hamels | 4 | 16 | 6 | 207 | 3.12 | 1.10 |
| Brandon Webb | 5 | 19 | 5 | 170 | 2.78 | 1.25 |
| Roy Halladay | 6 | 18 | 5 | 213 | 3.27 | 1.09 |
| Dan Haren | 7 | 16 | 6 | 202 | 3.45 | 1.20 |
| Francisco Liriano | 8 | 14 | 4 | 195 | 3.62 | 1.20 |
| Chad Billingsley | 9 | 17 | 6 | 218 | 3.41 | 1.29 |
| Jake Peavy | 10 | 16 | 5 | 187 | 3.06 | 1.21 |
| Josh Beckett | 11 | 18 | 8 | 185 | 3.98 | 1.19 |
| John Lackey | 12 | 15 | 7 | 152 | 3.57 | 1.22 |
| Cliff Lee | 13 | 17 | 6 | 172 | 3.10 | 1.25 |
| Felix Hernandez | 14 | 14 | 5 | 213 | 3.24 | 1.32 |
| Ervin Santana | 15 | 12 | 4 | 197 | 3.67 | 1.17 |
| Rich Harden | 16 | 13 | 4 | 188 | 3.02 | 1.05 |
| James Shields | 17 | 15 | 5 | 167 | 3.73 | 1.16 |
| Daisuke Matsuzaka | 18 | 19 | 4 | 157 | 3.31 | 1.31 |
| John Lester | 19 | 18 | 6 | 152 | 3.63 | 1.32 |
| A.J Burnett | 20 | 18 | 7 | 231 | 4.16 | 1.34 |
| Scott Kazmir | 21 | 12 | 6 | 153 | 3.74 | 1.29 |
| Joba Chamberlain | 22 | 13 | 7 | 194 | 4.13 | 1.30 |
| Roy Oswalt | 23 | 17 | 9 | 162 | 3.52 | 1.27 |
| Edison Volquez | 24 | 17 | 7 | 210 | 3.61 | 1.40 |
| Carlos Zambrano | 25 | 16 | 6 | 152 | 3.43 | 1.33 |